A genetic test designed to reduce the risk of having a child with an inherited condition

For people who know they are at increased risk of passing on a specific genetic condition.

PGT-M, or preimplantation genetic testing for monogenic/single gene defects, can be performed prior to pregnancy to greatly reduce the risk of having an affected child.

PGT-M involves testing embryos created through in vitro fertilization (IVF) and then transferring unaffected embryos.


This product is available for sale in selected countries around the world.


In the last ten years we have performed over 15,000 PGT-M cases on >1,000 different disorders 1

Who is it for?

PGT-M is appropriate for people who are at high-risk of passing on a specific single gene disorder. You may consider PGT-M if:

  • You and your partner are carriers of the same autosomal recessive condition (e.g. Cystic fibrosis)
  • You are a carrier of an X-linked condition (e.g. Duchenne Muscular Dystrophy)
  • You or your partner have an autosomal dominant condition (e.g. Huntington disease)
  • You or your partner have a mutation associated with a hereditary cancer syndrome (e.g. BRCA1 & 2)
  • You had a child or pregnancy with a single gene disorder
  • You want to perform HLA matching

PGT-M Technology

PGT-M testing involves a close examination of both the mutation an individual carries and the area of the chromosome surrounding it, shown above as the colored segment of each chromosome. Each PGT-M test design is unique and specific to the family, so DNA samples from both partners, and often additional family members, will be requested in order to design a test. Then, linkage analysis is used to determine the “genetic fingerprint” of the mutation and diagnose each tested embryo as affected or unaffected.

The PGT-M/SR Experience

CooperSurgical is the pioneer and worldwide leader of PGT-M/SR. Our team performed the first-ever PGT-M procedure, and has since performed more PGT-M/SR cases than all other labs combined. This level of experience allows us to confidently accept even the most complex cases, which are often turned down by other labs.

The PGT-M Process


Case review

Ordering provider submits a TRF along with genetic testing reports for case review and approval.


Genetic consultation

Registered patients speak with a genetic counselor
(PGT-M: discuss if additional genetic testing of the couple or other family members is required).


PGT-M process

PGT lab collects DNA samples from the couple and appropriate family members and designs a test unique to each family.



In vitro fertilization is performed and the resulting embryos are incubated


Embryo biopsy

An embryologist carefully removes a small cell sample from each embryo.



Embryos are frozen while awaiting PGT results.



Biopsied samples are sent to the PGT laboratory, testing is performed, and results are released to the IVF center.


Embryo transfer

If available, a chromosomally normal embryo is selected for transfer. Additional euploid embryos can remain frozen for future use.

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