This website contains information intended solely for healthcare professionals. It is not meant for patients or the general public and should never replace professional medical advice, diagnosis, or treatment. Patients should not rely on this content for decisions about their health or medical care. If you are a patient and have questions about a CooperSurgical Genomics test or its implications, please contact your healthcare provider. Your provider can explain the benefits, risks, and limitations of the test and help determine whether it is appropriate for you.
PGT-M
Fast-Track PGT-M℠ Testing: Empowering Families and Clinicians
Leveraging cutting-edge amplification technology to provide a new premium Fast-Track PGT-M service.
What to expect
Fast-Track PGT-M
4 weeks*
Benefits of Fast-Track PGT-M testing
Improved patient experience
Could facilitate earlier IVF cycling**
Designed to streamline the PGT-M process for clinics and patients
A legacy of PGT innovation
CooperSurgical boasts 30+ years of PGT-M experience, with over 10,000 procedures conducted.1 Our technology continues the tradition established by those pioneers who performed the first PGT-M cases,2 and played an integral role in shaping our genomics organization.
Fast-Track PGT-M service
We’re excited to introduce a revolutionary amplification technology, unique to CooperSurgical, that will improve the patient experience while streamlining processes for the clinician.
*All referred qualifying PGT-M cases will be subject to a 4-week turnaround that is initiated upon completion of case acceptance and receipt of required materials
**Following case review and acceptance
1. Internal CooperSurgical data
2. Handyside, A. H., et al. (1992). Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis. The New England journal of medicine, 327(13), 905–909. https://doi.org/10.1056/NEJM199209243271301
High accuracy – Improved genome coverage leads to better confidence in our results
For people who know they are at increased risk of passing on a specific genetic condition.
PGT-M, or preimplantation genetic testing for monogenic/single-gene defects, can be performed prior to pregnancy to greatly reduce the risk of having an affected child.
PGT-M involves testing embryos created through in vitro fertilization (IVF) and then transferring unaffected embryos.
In the last ten years we have performed over 15,000 PGT-M cases on >1,000 different disorders 1
What it can do
- Report which embryos, if any, have inherited the disorder in question
- Allow unaffected embryos, if available, to be prioritized for transfer
- Significantly lower the risk of passing the known familial genetic disorder(s) to your children
What it does not do
- Evaluate for chromosome abnormalities
- Identify genetic conditions other than the specific disorder in question
- Guarantee the birth of a healthy baby
PGT-M Technology
PGT-M testing involves a close examination of both the mutation an individual carries and the area of the chromosome surrounding it, shown above as the colored segment of each chromosome.
Each PGT-M test design is unique and specific to the family, so DNA samples from both partners, and often additional family members, will be requested in order to design a test.
Then, linkage analysis is used to determine the “genetic fingerprint” of the mutation and diagnose each tested embryo as affected or unaffected.
The PGT-M Process
1
PGT-M Referral Receipt and Processing
Client Services (CS) receives PGT-M referral (completed test requisition form and genetic test reports) and our genetic counseling team is assigned the case for review.
Up to 2 business days
2
Family History Collection
The referred family is invited to share important family history information with our genetic counseling team. Receipt of this information is requested to proceed with PGT-M.
Patient dependent
3
PGT-M Case Review
Our genetic counseling team carefully reviews the PGT-M test order, provided genetic testing reports, and the submitted family history information.
Up to 3 business days
4
Financial Consult and Patient Consent
If a case is accepted for PGT-M, our Client Services team will contact the patient to review PGT fees and insurance details, if applicable. Completion of necessary payment arrangements, review and signature of provided consent forms are required to move forward with PGT-M.
Patient dependent
5
Genetic Counseling Consultation
Patients moving forward with PGT-M are invited to schedule an appointment to speak with one of our genetic counselors about PGT-M and their specific case.
On scheduled date
6
Case Acceptance
A letter summarizing the plan for the case and any special requirements is sent to the clinic. This communication includes information about whether biopsied embryo samples may be submitted.
Up to 5 business days
7
DNA Collection
DNA collection kits are sent to the family and designated family members, after all case requirements (e.g., payment arrangements and returning of signed consent forms) have been completed.
Patient dependent
8
Biopsy Samples Submitted
Clinic initiates IVF cycle start according to its protocols and availability. Biopsied embryo samples are submitted to the genomics laboratory.
Clinic dependent laboratory
9
PGT-M Test Optimization and Result Reporting
Initial PGT-M test optimization, sample testing, and result reporting take 4 weeks* for the first group of samples. Subsequent cycles yield PGT-M results within 15 calendar days.
Dependent on receipt of samples
1
PGT-M Referral Receipt and Processing
Customer Support (CS) receives PGT-M referral (completed test requisition form, genetics test reports and family history form; e.g., via the genomics portal) and our genetic counseling team is assigned the case for review.
Up to 2 business days
2
PGT-M Case Review
Our genetic counseling team carefully reviews the PGT-M test order, provided genetic testing reports, and the submitted family history information.
Up to 3 business days
3
Genetic Counseling Consultation
Clinic dependent. Patients moving forward with PGT-M are invited to schedule an appointment to speak with one of our genetic counselors about PGT-M and their specific case.
On scheduled date
4
Case Acceptance
A letter summarizing the plan for the case and any special requirements is sent to the clinic. This communication includes information about whether biopsied embryo samples may be submitted. At this stage, patients are also sent consents to sign and return.
Up to 5 business days
5
DNA Collection
DNA collection kits are sent to the family and designated family members, after all case requirements have been completed.
Patient dependent
6
Biopsy Samples Submitted
Clinic initiates IVF cycle start according to its protocols and availability. Biopsied embryo samples are submitted to CooperSurgical genomics laboratory.
Clinic dependent
7
PGT-M Test Optimization and Result Reporting
Initial PGT-M test optimization, sample testing, and result reporting take 4 weeks* for the first group of samples. Subsequent cycles yield PGT-M results within 14 calendar days.
Dependent on receipt of samples
*All referred qualifying PGT-M cases will be subject to a 4-week turnaround that is initiated upon completion of case acceptance and receipt of required materials.
Brochures, Catalogs & Flyers
Fast-Track PGT-M Clinician Brochure
Fast-Track PGT-M Clinician Brochure
PGT-M Patient Brochure
PGT-M Patient Brochure
Fast-Track Testing Process
Fast-Track Testing Process
Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) is a genetic test intended only as a screening tool. PGT-M analysis is limited to the disorder(s) for which testing has been ordered. It is not a diagnostic test and cannot detect all genetic variants (mutations), abnormalities, or health conditions. Healthcare providers should review the test’s indications, limitations, and potential risks and discuss these with their patients to determine whether the test is appropriate for the patient’s individual circumstances. Because PGT-M is customized for each family, it only evaluates for the single-gene disorder(s) for which testing has been ordered. It does not evaluate for sporadic chromosome abnormalities or for any other genetic disorders. It does not guarantee the birth of a healthy baby. Medical guidelines and healthcare providers recommend that any pregnancy resulting from an embryo screened with this test undergo confirmatory diagnostic testing, such as chorionic villus sampling (CVS) or amniocentesis, to verify genetic status.
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