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Endosee™ Advance
See now. Know now.™

Designed to make in-office hysteroscopy easy, efficient and patient-friendly

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Endosee-handheld-version2

A compact, all-in-one, handheld hysteroscopy system designed for in-office use without the need for bulky equipment or a dedicated procedure room.1,2

It is lightweight and designed to fit easily in a white coat pocket, allowing for portability and accessibility in your practice

One Device. Countless Moments of Clarity.

From routine evaluations to the unexpected, Endosee® Advance supports a wide spectrum of gynecologic decision‑making. Its direct visualization gives you real‑time insight to assess abnormalities, investigate symptoms, guide targeted treatment and biopsy, and manage intrauterine concerns—all without leaving the exam room.3-5

See now. Know now.™

Explore the benefits of bringing in-office hysteroscopy across your practice, your patients, and your team

Endosee Advance not only improves diagnostics but also enhances the patient experience and practice efficiency.

See clearly, diagnose confidently

The first time you directly visualize the uterus can be in your office.

Endosee-advance-faceon

Advanced optics deliver exceptional clarity and a wide field of view for more precise evaluations.2

Vivid color display facilitates identification of structural causes of AUB.7

Intuitive controls help maintain smooth, stable imaging—even for first-time users.7

With Endosee® Advance, you can:

Visualize tissue directly to determine if targeted biopsy is needed.4

Confirm structural abnormalities.4

Achieve superior diagnostic accuracy with enhanced sensitivity and specificity.6

Make confident treatment decisions at the point of care visit. Endosee Advance can elevate your diagnostic capabilities by providing instant endometrial imaging guided by direct visualization.3

Reduce patient worry and increase diagnostic confidence3,4

Lessen patient anxiety

Patients can undergo procedures in the familiar setting of their doctor’s office.3

Faster recovery

Patients report faster recovery times versus OR cases, enabling them to turn to their daily routines sooner.3

Higher patient satisfaction

Patients report greater satisfaction

Minimize financial burden

Patients may avoid unnecessary operating room (OR) visits and associated costs.3

Same-day answers

Immediate diagnostic insights to help you
determine next steps.3

Reduce risks associated with general anesthesia

Patients can avoid the adverse effects of general anesthesia.3

Endosee Advance provides immediate diagnostic insights potentially avoiding hospital visits, resulting in faster recovery than the OR and providing patients peace of mind.3

Transform any room into a hysteroscopy-ready space with the Endosee Advance

Endosee® Advance enables seamless integration into any standard exam room, designed for convenient use without requiring special set up.5

See now

Direct in-office inspection of the endometrium for uterine health concerns in

Average total time doctor is in exam room is

Know now

Progress patient care by identifying the next step and whether surgical intervention is necessary.4

Endosee® Advance is a portable, all-in-one hysteroscopy system with single-use cannula that can enable real-time diagnosis and treatment in the office—improving efficiency and workflow without the need for the operating room or general anesthesia.2,4

Capture value and reduce costs with Endosee® Advance

By bringing hysteroscopic procedures in-office, your practice can capture additional revenue streams while reducing patient financial burden compared to hospital-based alternatives.8

Office-based hysteroscopy has been shown to reduce costs by approximately 50% compared to OR procedures.9

practice-50percent

In a study of 130 AUB patients at two outpatient clinics:

avoided the OR with in-office hysteroscopy.8

Endosee® Advance procedures are coded and reimbursed as Hysteroscopy.10

practice-graph-new-ref-10

Note that the reported RVUs are based on the 2025 coding guide.

With Endosee® Advance, you can deliver high-quality, cost-effective care, while capturing revenue that would otherwise be sent to the OR.8

See clearly, diagnose confidently

The first time you directly visualize the uterus can be in your office.

Endosee-advance-faceon

Advanced optics deliver exceptional clarity and a wide field of view for more precise evaluations.2

Vivid color display facilitates identification of structural causes of AUB.2

Intuitive controls help maintain smooth, stable imaging—even for first-time users.2

With Endosee® Advance, you can:

Visualize tissue directly to determine if targeted biopsy is needed.4

Confirm structural abnormalities.4

Achieve superior diagnostic accuracy with enhanced sensitivity and specificity.6

Make confident treatment decisions at the point of care visit. Endosee Advance can elevate your diagnostic capabilities by providing instant endometrial imaging guided by direct visualization.4

Reduce patient worry and increase diagnostic confidence3,4

Lessen patient anxiety

Patients can undergo procedures
in the familiar setting of their
doctor’s office.3

Faster recovery

Patients report faster
recovery times versus OR
cases, enabling them to
turn to their daily routines
sooner.3

Higher patient satisfaction

Patients report greater satisfaction

Minimize financial burden

Patients may avoid unnecessary operating room (OR) visits and associated costs.3

Same-day answers

Immediate diagnostic
insights to help you
determine next steps.3

Reduce risks associated
with general anesthesia

Patients can avoid the adverse effects of general anesthesia.3

Endosee Advance provides immediate diagnostic insights potentially avoiding hospital visits, resulting in faster recovery than the OR and providing patients peace of mind.3

Transform any room into a hysteroscopy-ready space with the Endosee Advance

Endosee® Advance enables seamless integration into any standard exam room, designed for convenient use without requiring special set up.5

See now

Direct in-office inspection of the endometrium for uterine health concerns in

Average total time doctor is in exam room is

Know now

Progress patient care by identifying the next step and whether surgical intervention is necessary.4

Endosee® Advance is a portable, all-in-one hysteroscopy system with single-use cannula that can enable real-time diagnosis and treatment in the office—improving efficiency and workflow without the need for the operating room or general anesthesia.2,4

Capture value and reduce costs with Endosee® Advance

By bringing hysteroscopic procedures in-office, your practice can capture additional revenue streams while reducing patient financial burden compared to hospital-based alternatives.8

Office-based hysteroscopy has been shown to reduce costs by approximately 50% compared to OR procedures.9

practice-50percent

In a study of 130 AUB patients at two outpatient clinics:

avoided the OR with in-office hysteroscopy.8

Endosee® Advance procedures are coded and reimbursed as Hysteroscopy.10

practice-graph-new-ref-10

Note that the reported RVUs are based on the 2025 coding guide.

With Endosee® Advance, you can deliver high-quality, cost-effective care, while capturing revenue that would otherwise be sent to the OR.8

Endosee® Advance Features

+ + Reusable display module with large,
high resolution color LCD touchscreen2 x Exceptional image quality every time,
with an integrated camera and light
source, no lens degradation or
sterilization required.2 x 4.3 mm distal tip requires minimal
dilation for improved patient comfort2 x Sterile, single-use cannula balances
flexibility and stiffness for ease of insertion2 Single action scissors Alligator grasper forceps Biopsy forceps Disposable retrieval snare + Fluid Infusion Port: Enables gentle uterine
distension and continuous cavity
clearing via syringe or pressurized
bag to support clear visualization during
office hysteroscopy.2 x x Docking station for easy image
transfer and charging2 x Working channel compatible with 5Fr
therapeutic instruments, including:2 x Wireless, portable, and convenient
to use in any room2,5 x Still image and video capture with
transfer to computer and electronic
health record systems2 x Ergonomic handheld design
for control and ease of use2 + + + + + + x +

Endosee® Advance Features

1

Exceptional image quality every time, with an integrated camera and light source, no lens degradation or sterilization required.2

2

4.3 mm distal tip requires minimal dilation for improved patient comfort2

3

Sterile, single-use cannula balances flexibility and stiffness for ease of insertion2

4

Docking station for easy image transfer and charging2

5

Fluid Infusion Port: Enables gentle uterine distension and continuous cavity clearing via syringe or pressurized bag to support clear visualization during office hysteroscopy.2

6

Still image and video capture with transfer to computer and electronic health record systems2

7

Ergonomic handheld design for control and ease of use2

8

Reusable display module with large, high resolution color LCD touchscreen2

9

Working channel compatible with 5Fr therapeutic instruments, including:2

Single action scissors

Disposable retrieval snare

Alligator grasper forceps

Biopsy forceps

10

Wireless, portable, and convenient to use in any room2,5

Request a Demonstration

Standard approaches to Abnormal Uterine Bleeding (AUB) evaluation may leave questions unanswered.

While EMB and TVUS may be necessary in the diagnosis of AUB, understanding their limitations is important for recognizing when additional diagnostic insight may be needed.

Patient history

Provides essential clinical context, although symptoms alone may not identify the underlying etiology.11,13

TVUS

Provides structural imaging of the uterus, but cannot directly visualize the endometrial surface or distinguish between similar-appearing lesions.11,13

In-office hysteroscopy

Provides direct visualization of the endometrial lining, enabling visual diagnosis of focal lesions that may be missed by EMB, TVUS, and saline-infused sonohysterography (SIS).12

EMB

Samples the endometrium and can detect various endometrial pathologies, but a negative result alone is insufficient for definitive diagnosis.11,14

In-office hysteroscopy may help to complete the diagnostic picture by allowing clinicians to inspect the uterine cavity, identify focal abnormalities, and assess structural abnormalities, providing patients with a clearer diagnosis.12

Complete your AUB diagnostic workflow with Endosee

Direct visualization allows you to gain immediate clarity at the point of care.

Endosee-HCP-brochure-mockup

Endosee® Advance HCP Brochure

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Endosee-patient-peel-graphic

Endosee® Patient Brochure

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Clinicians’ Experience with Endosee Advance

Allows Physicians & Patients To Move Further Down The Diagnostic Algorithm “Whether it’s seeing something or not seeing something, Endosee allows both physicians and patients to move further down the diagnostic algorithm or pathway. Patients are so appreciative that they can see and know exactly what’s going on instead of having to come back for a follow-up visit or wait for a laboratory result. By using it, you realize that you’re doing patients a service by getting to a diagnosis as soon as possible.”5

“In addition to offering physicians immediate visualization to gather important diagnostic information, Endosee also allows us to perform an endometrial biopsy and hysteroscopy in the same visit.”5 Ethan Goldstein, MD Robotic & Minimally Invasive Surgery Program, Huron Valley-Sinai Hospital, Detroit, MI The Standard of Care Has Changed “The standard of care has changed. Now the standard of care corroborates that a negative blind biopsy is not a stopping point. Clinicians can still begin with a blind biopsy, but unless it is malignant or complex atypical hyperplasia, the endometrial evaluation is not complete. One of the take-home messages is getting away from this over-reliance on blind biopsy as the first and last word in all these cases.”16 Steven R. Goldstein, MD New York University School of Medicine, New York, NY A More Thorough Evaluation, Faster Diagnosis “I had a patient with persistent post-menopausal bleeding with a normal endometrial biopsy and transvaginal ultrasound, but I decided to also use Endosee because it is so easy to set up and poses such a low risk. Much to my surprise, I ended up finding one of the largest endometrial polyps I have ever seen. I would never have found this polyp had I not used Endosee since I probably would not have taken her to the OR or even done office hysteroscopy because I thought I wouldn’t find anything. But because Endosee is so quick and easy to use, I found significant pathology, treated the patient and her symptoms are completely resolved.”17 Abigail T. Feathers, MD Specialty Physicians of Garrett County
Oakland, MD / 0{{total_slide_count}} 0{{current_slide_index}}
Request a Demonstration

Endosee Advance Videos and Podcasts

Physician Education

A New and Better Standard of Care Than Blind Biopsy for the Diagnosis of Abnormal Uterine Bleeding

Recent advances in technology are significantly changing the way physicians evaluate patients with abnormal uterine bleeding (AUB). Join host Dr. Andrea Singer as she welcomes Dr. Steven R. Goldstein to discuss AUB and Endosee®, and in-office diagnostic hysteroscopy.
Featuring Endosee Office Hysteroscopy device.

Part 1: Abnormal Uterine Bleeding (AUB): Impact of Direct Visualization for Earlier Diagnosis

Endometrial biopsy (EMB) has limitations in detecting abnormalities within the uterine cavity. In Part 1 of this two-part series, hear experts share their perspectives.

Part 2: Endosee®– Changing the Work Up of Abnormal Uterine Bleeding (AUB)

In this second discussion of a 2-part series, host Dr. Renee Allen welcomes back gynecologic experts as they discuss “Endosee®: Changing the Work Up of Abnormal Uterine Bleeding (AUB)

Set-up and Demonstration

System Overview & General Operation Brief overview including components, working channel instruments, assembly, video and still capture. Watch Pre-Procedure Setup List of supplies needed for procedure, including optional supplies. Patient pretreatment options. Watch Patient Workup – Ethan Goldstein Watch Ethan Goldstein, M.D. discuss how using Endosee has improved the AUB patient care workflow at his practice. Watch Patient Examination Procedure Entering Patient ID, system assembly, performing diagnostic and therapeutic procedures, post-procedure steps including cleaning, recharging. Watch Endosee Case Setup and Procedure – Ethan Goldstein Setting up Endosee is simple and fast. See a real practice setup and use Endosee for office hysteroscopy. Watch Endosee Advance See Now, Know Now – Ethan Goldstein FAQ video In-office Direct Visualization for AUB patients. An overview of what patients can expect, before, during and after, with… Watch Endosee Advance Overview Animation Watch a 3-minute animation highlighting the product’s in-office hysteroscopy capabilities. Watch

Product Codes

Product Order Code
Endosee Advance Display Module (1 unit)ES9000
Endosee Cannula, compatible with ES9000 only (5 per Box)ESPX5
Endosee System Convenience Kit (5 per Box)ES-TRAY
Biopsy forcepsES-BPSY
Spoon Forceps, Long SerratedES- LNGR
Foreign Body Grasper, FenestratedES-FBGR
Scissors, Single ActionES-SCIS
Disposable Alligator Grasper Forceps, 5FR; 460 mmES- DISP- AGR
Disposable Single Action Scissors. 5FR; 460mmES-DISP-SCS
Disposable Biopsy Forceps, 5FR,460mmES-DISP- BPY
Disposable Retrieval Snare, 5 Fr. 465 mm, 5/BoxES-DISP-10-BL
Disposable Retrieval Snare, 5 Fr. 473 mm, 5/BoxES-DISP-15-BL

Brochures, Catalogs & Flyers

Endosee Advance HCP Brochure

Endosee Patient Brochure

Endosee Advance Overview

Endosee Advance Accessories and Instruments Summary

Clinic Catalog

Endosee Advance Instructions for Use
Endosee Reusable Instruments Instructions for Use
Endosee Single Use Instrument Guide
Endosee Advance Reimbursement Guide
Endosee® Advance Accessories & Instruments
Endosee Advance Practice Change Guide

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Contact your local representative for more information

   

IMPORTANT SAFETY INFORMATION
Endosee® Advance Direct Visualization System is indicated for viewing the cervical canal, uterine cavity, or female urinary tract, for the purpose of performing diagnostic and therapeutic procedures. Hysteroscopy is contraindicated in patients with known or suspected pelvic inflammatory disease. Hysteroscopy may be contraindicated in patients with inability to distend the uterus, cervical stenosis, cervical/vaginal infection, uterine bleeding, menses, known pregnancy, invasive carcinoma of the cervix, recent uterine perforation, or intolerance to anesthesia. Cystoscopy is contraindicated in patients with severe coagulopathy or febrile patients with urinary tract infection. Please refer to Instructions for Use for more information.

References

  1. Anderson T. Hand-held digital hysteroscopy system—a game-changer: If you suffer from technophobia, ergonophobia, or econophobia, this device is for you. Contemp Ob/Gyn. 2016;61:29-34.
  2. CooperSurgical, Inc. Endosee® Advance Direct Visualization System Display Module, Docking Station, and Cannula: Instructions for Use. Trumbull, CT; June 2022:1-20.
  3. American College of Obstetricians and Gynecologists (ACOG). The use of hysteroscopy for the diagnosis and treatment of intrauterine pathology: ACOG Committee Opinion No. 800. Obstet Gynecol. 2020;135(3):e138-e148.
  4. Bradley LD. “Blind” endometrial sampling: A call to end the practice. OBG Management. 2022;34(11):33-38.
  5. Goldstein E. Advantages of in-office hysteroscopy in the diagnosis of abnormal uterine bleeding with Endosee®. CooperSurgical. 2017:1.
  6. Grimbizis GF, Tsolakidis D, Mikos T, et al. A prospective comparison of transvaginal ultrasound, saline infusion sonohysterography, and diagnostic hysteroscopy in the evaluation of endometrial pathology. Fertil Steril. 2010;94(7):2720-2725.
  7. Endosee® Advance Case Study – Data on File. CooperSurgical; 2019.
  8. Moawad N, Santamaria E, Johnson M, Shuster J. Cost effectiveness of office hysteroscopy for abnormal bleeding. JSLS. 2014;18(3):1-5.
  9. Munro MG, Critchley HO, Fraser IS. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years. Fertil Steril. 2011;95(7):2204-2208, 2208.e1-3.
  10. Centers for Medicare & Medicaid Services. Physician Fee Schedule Search. CMS. Available at: https://www.cms.gov/medicare/physician-fee-schedule/search. Accessed May 26, 2026.
  11. Johns Hopkins Medicine. Sonohysterography. 2025. Available at: https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/sonohysterography. Accessed June 9, 2025.
  12. Bradley LD. Diagnosis of abnormal uterine bleeding with biopsy or hysteroscopy. Menopause. 2011;18(4):425-433.
  13. Lee SC, Seibel B, Kaunitz AM. When should endometrial polyps be treated? Curr Obstet Gynecol Rep. 2012;1:89-93. doi:10.1007/s13669-012-0012-9.
  14. American College of Obstetricians and Gynecologists (ACOG). Practice bulletin no. 128: Diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstet Gynecol. 2012;120(1):197-206.
  15. ACOG. Management of acute abnormal uterine bleeding in nonpregnant reproductive-aged women. Obstet Gynecol. 2013;121(4):891-896.
  16. Postmenopausal Bleeding Requires More Than Blind Biopsy. Medscape. November 13, 2017. Available at: https://www.medscape.com/viewarticle/888432_print.
  17. Feathers AT. Endosee Has Proven to be Helpful for a Number of Patients, Both Young & Old. CooperSurgical 82564 06/16.